FDA-approved Prescription Eyedrops
to lift your upper eyelids

Get an Eye-Opening Lift with a Daily Drop of Upneeq®

Upneeq eyedrops are a revolutionary new treatment for droopy eyelids that are backed by years of scientific research and development. The active ingredient in Upneeq, oxymetazoline, has been used in other medications for decades and is well-known for its ability to constrict blood vessels and reduce inflammation. When applied topically to the eyelids, Upneeq works by stimulating the muscles responsible for lifting the eyelid, resulting in a more youthful, alert appearance.

Clinical studies have shown that Upneeq can be highly effective at improving eyelid position and symmetry, with noticeable results visible in as little as five minutes. So if you’re looking for a safe, non-invasive way to enhance the natural beauty of your eyes, Upneeq may be just what you’ve been searching for.



Right before and after image: Actual patient image courtesy of Dr. Robert Schwarcz. Individual results may vary. Average upper eyelid lift with Upneeq in clinical studies was 1 mm.


The Science of Upneeq®

Upneeq contains the active ingredient oxymetazoline, which is a type of medication known as a sympathomimetic. Sympathomimetics work by stimulating the sympathetic nervous system, which is responsible for regulating a variety of physiological processes in the body, including blood pressure, heart rate, and muscle tone.

When Upneeq is applied topically to the eyelids, oxymetazoline works by constricting the blood vessels in the area. This results in a reduction in inflammation and swelling, which can cause droopy eyelids.

But that’s not all. Oxymetazoline also has a unique effect on the muscles responsible for lifting the eyelids. Specifically, it stimulates the muscle fibers of the levator palpebrae superioris muscle, which is the muscle that controls eyelid elevation. This stimulation causes the muscle to contract more strongly, resulting in a visible lifting of the eyelid.

The result is a more alert, youthful appearance, with a reduction in the appearance of droopiness and asymmetry in the upper eyelids. Clinical studies have shown that the effects of Upneeq can last for several hours, making it a convenient and effective way to enhance the natural beauty of your eyes without the need for surgery or other invasive procedures.


Ready to start your journey?





What is UPNEEQ?

UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults.

What warnings and precautions are associated with UPNEEQ?

  • Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.
  • UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
  • Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.
  • UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
  • Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used.

What are the most common side effects of UPNEEQ?

The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.

What should my doctor know about before prescribing me UPNEEQ?

  • Your doctor should review your full medical history before prescribing UPNEEQ.
  • UPNEEQ belongs to a class of medication (alpha-adrenergic agonists) that may affect your blood pressure. Use UPNEEQ carefully if you currently take an alpha-adrenergic agonist medication to treat heart disease or an enlarged prostate. Patients taking beta-blockers, or other medications to treat hypertension or an abnormal heartbeat, should also be careful when using UPNEEQ.
  • Patients who use a certain class of antidepressant medication (monoamine oxidase inhibitors) should also be careful when using UPNEEQ, as it may affect the way your body absorbs the medication.

These are not all of the possible side effects of UPNEEQ. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects.

To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch.

This is a summary of the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ.

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